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Journal of Biophotonics(2023)
Intraoperative application of optical
coherence tomography for lung tumor

生醫工程研究所 孫家偉 教授（通訊作者）

On-site instant determination of benign or malignant tumors for deciding the types of resection is
crucial during pulmonary surgery. We designed a portable spectral-domain optical coherence

tomography (SD-OCT) system to do real-time scanning intraoperatively for the distinction of fresh

tumor specimens in the lung. A total of 12 ex vivo lung specimens from six patients were enrolled.
Three patients were diagnosed with invasive adenocarcinoma (IA), while the others were benign.

After OCT-imaged reconstruction, we compared the qualitative morphology of OCT and histology
among malignant, benign, and normal tissues. In addition, through analysis of the quantitative data, a

discrete difference in optical attenuation coefficients around the junctional surface was shown by our
data processing. This study demonstrated a feasible OCT-assisted resection guide by a rapid on-site

tumor diagnosis. The results indicate that future deep learning of OCT-captured image systems able to

improve diagnostic and therapeutic efficiency is warranted.

IEEE Transactions on Industrial Electronics
Unequal Duty-Ratio Feedforward Control to
Extend Balanced-Currents Input Voltage Range
for Series-Capacitor-Based Boost PFC Convert

電控工程研究所 陳鴻祺 教授（第一作者）

In this letter, the series-capacitor-based boost power factor correction (PFC) converter (or called
the voltage doubler PFC converter) is studied. It possesses the voltage doubler and intrinsic current

balancing characteristics only when their equal duty ratios are larger than 0.5. Thus, for PFC

application, the balanced-currents input voltage should be smaller than the quarter (1/4) output dc
voltage. To extend the balanced-currents input voltage range, the unequal duty-ratio feedforward

control is proposed in this letter. For the case of dc output voltage 400 V, the maximum input voltage
with balanced inductor currents increased from 100 V (the quarter output dc voltage) to 200 V. The

proposed control method is implemented in the field programmable gate array chip to evaluate its
performance.

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